Chlorination increases the persistence of semiquinone free radicals derived from polychlorinated biphenyl hydroquinones and quinones

…, BA Wagner, LW Robertson, HJ Lehmler

文献索引：Song, Yang; Buettner, Garry R.; Parkin, Sean; Wagner, Brett A.; Robertson, Larry W.; Lehmler, Hans-Joachim Journal of Organic Chemistry, 2008 , vol. 73, # 21 p. 8296 - 8304

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被引用次数: 50

摘要

Polychlorinated biphenyls (PCBs) comprise a group of persistent organic pollutants that differ significantly in their physicochemical properties, their persistence, and their biological activities. They can be metabolized via hydroxylated and dihydroxylated metabolites to PCB quinone intermediates. We have recently demonstrated that both dihydroxy PCBs and PCB quinones can form semiquinone radicals (SQ•−) in vitro. These semiquinone radicals are ...