Tetrahedron

Practical synthesis of indolopyrrolocarbazoles

…, T Nishimura, H Jona, T Honma, H Morishima

文献索引：Ohkubo, Mitsuru; Nishimura, Teruyuki; Jona, Hideki; Honma, Teruki; Morishima, Hajime Tetrahedron, 1996 , vol. 52, # 24 p. 8099 - 8112

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被引用次数: 123

摘要

A practical method for the synthesis of an indolo [2, 3-a] pyrrolo [3, 4-c] carbazole ring system is described. The method involves two key processes: a coupling reaction between indole and substituted methylmaleimide portions using lithium hexamethyldisilazide (LiHMDS) as a base, and the oxidative cyclization of bisindolylmaleimide with palladium (II) chloride. We applied this method to the synthesis of arcyriaflavin B (5), C (6) and D (7).