The synthesis and activity of some 2, 6-difluorophenyl-substituted compounds

AM Roe, RA Burton, GL Willey…

文献索引：Roe,A.M. et al. Journal of Medicinal Chemistry, 1968 , vol. 11, # 4 p. 814 - 819

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被引用次数: 37

摘要

. I witit. variety of~~ liarinacoiogicsll~~ active 1, 2, 3-trisnhstitutrtl: mimitic compounds in m- hic, h the 1 xiid 3 srihstituciits are chlorine or methyl have been described.'l'hcse iticlitdc the local anesthetics lidocaine (28). l'1-(L', Ci-dicliloroi, lieiio~ y) ethyldiineth!,-laniiIlc.(14), mid syloclioline (19), aiid the adreiiergic iieuroiie blocliiiig drugs ryloclioliiir (19) arid its giiariidino analog (11). This~) xi) cr dtwribes the completiori of thc seriw of crJni!) ourids to ...