Tetrahedron

Benzoheterocycles via aryne C− C cyclisation: Initial approaches

B Jaques, RG Wallace

文献索引：Jaques,B.; Wallace,R.G. Tetrahedron, 1977 , vol. 33, p. 581 - 588

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被引用次数: 16

摘要

The preparation of some benzo-4, 5 and 6-membered mononitrogen heterocycles by cyclisation of an aryne with a side chain carbanion α to a cyanide group has been investigated: Thus 1-cyano-2-methyl-1, 2, 3, 4-tetrahydroisoquinoline,(50%); 4-cyano-1-ethyl- 1, 2, 3, 4-tetrahydroquinoline,(11%) 2-methylisoindole,(89%) have been prepared. Attempts to prepare an N-acetyl indoline gave 2-methylbenzoxazole, and a benzazetine approach ...