A novel series of potent and selective IKK2 inhibitors
…, RJ Davenport, L Gowers, RL Knight, C Lowe…
文献索引：Bingham, Alistair H.; Davenport, Richard J.; Gowers, Lewis; Knight, Roland L.; Lowe, Christopher; Owen, David A.; Parry, David M.; Pitt, Will R. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 2 p. 409 - 412
A novel series of aminopyrimidine IKK2 inhibitors have been developed which show excellent in vitro inhibition of this enzyme and good selectivity over the IKK1 isoform. The relative potency and selectivity of these compounds has been rationalized using QSAR and structure-based modelling.
