Highly Enantioselective Hydrogen??Transfer Reductive Amination: Catalytic Asymmetric Synthesis of Primary Amines

R Kadyrov, TH Riermeier

文献索引：Kadyrov, Renat; Riermeier, Thomas H. Angewandte Chemie - International Edition, 2003 , vol. 42, # 44 p. 5472 - 5474

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被引用次数: 163

摘要

Optically active amines are attracting increasing interest in the food, agrochemical, and pharmaceutical industries as building blocks for novel compounds and as templates for asymmetric synthesis. One of the most common methods for preparing amines is the reductive amination of carbonyl compounds.[1] We have successfully explored the rhodiumcatalyzed asymmetric reductive amination with hydrogen as the reducing agent.[2 ...