Expanding the scaffold for bacterial RNA polymerase inhibitors: design, synthesis and structure–activity relationships of ureido-heterocyclic-carboxylic acids
... DOI: 10.1039/C3RA45820B (Paper) RSC Adv., 2014, 4 ... of the parent class I. 17 An increase of activity was also observed with substituents having larger hydrophobic volume at the ... Spontaneous resistance rate towards Myx B in S. aureus was found to be 4 to 7 × 10 −8 , similar to ...
