Tetrahedron letters

Asymmetric synthesis. XXXI. Synthesis of 2-substituted piperazines from chiral non-racemic lactams

V Schanen, C Riche, A Chiaroni, JC Quirion…

文献索引：Schanen, Vincent; Riche, Claude; Chiaroni, Angele; Quirion, Jean-Charles; Husson, Henri-Philippe Tetrahedron Letters, 1994 , vol. 35, # 16 p. 2533 - 2536

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被引用次数: 42

摘要

Download full text in PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... The preparation of lactam 2 from R-(-)-phenylglycinol and N-Boc glycine is described. Diastereoselective alkylation of 2 allowed the preparation of piperazine derivatives in an optically pure form. ... A series of 2-substituted piperazines 8 in enantiomerically pure form has been synthetized ...