4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: Urea-based analogs

SM Yang, Y Tang, R Zhang, H Lu, GH Kuo…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 24 p. 6773 - 6776

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被引用次数: 4

摘要

... Bioorganic & Medicinal Chemistry Letters. ... In our medicinal chemistry program toward novel SCD1 inhibitors, we envisioned a ring constrained strategy by tethering the key ortho-substituted carbon to either the ether oxygen position or carbonyl group position ( Fig. ...