Development of 2, 3-dihydro-6-(3-phenoxypropyl)-2-(2-phenylethyl)-5-benzofuranol (L-670,630) as a potent and orally active inhibitor of 5-lipoxygenase

…, PC Belanger, C Dufresne, J Scheigetz…

文献索引：Lau, Cheuk K.; Belanger, Patrice C.; Dufresne, Claude; Scheigetz, John; Therien, Michael; et al. Journal of Medicinal Chemistry, 1992 , vol. 35, # 7 p. 1299 - 1318

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被引用次数: 29

摘要

Leukotrienes are potent biological mediators of allergic and inflammatory diseases and are derived from arachidonic acid through the action of the 5-lipoxygenase. In this study, the syntheses and comparative biological activities of three series of 2, 3-dihydro-2, 6- disubstituted-5-benzofuranols with various substituents on position 3 are described. Compounds from each aeries were evaluated for their ability to inhibit the production of ...