Synthesis, antidepressant and antifungal evaluation of novel 2-chloro-8-methylquinoline amine derivatives

S Kumar, S Bawa, S Drabu, H Gupta, L Machwal…

文献索引：Kumar, Suresh; Bawa, Sandhya; Drabu, Sushma; Gupta, Himanshu; MacHwal, Lalit; Kumar, Rajiv European Journal of Medicinal Chemistry, 2011 , vol. 46, # 2 p. 670 - 675

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被引用次数: 19

摘要

A new series of N-[(2-chloro-8-methylquinolin-3-yl) methyl]-(substituted)-aniline/butylamine/ cyclohexylamine/benzylamine derivatives (4a–p) was synthesized by nucleophilic substitution reaction of 2-chloro-3-(chloromethyl)-8-methylquinoline 3 with various aliphatic and aromatic amines in absolute ethanol in the presence of triethylamine (TEA). The newly synthesized secondary amines were characterized by the combined use of IR, 1H NMR, ...