IOP-lowering effect of isoquinoline-5-sulfonamide compounds in ocular normotensive monkeys

…, Y Inoue, M Nishio, Y Naito, T Hosoya, M Suzuki…

文献索引：Sumi, Kengo; Inoue, Yoshihiro; Nishio, Masahiro; Naito, Yasuhito; Hosoya, Takamitsu; Suzuki, Masaaki; Hidaka, Hiroyoshi Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 3 p. 831 - 834

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被引用次数: 8

摘要

Abstract Rho-associated coiled coil-formed protein kinase (ROCK) inhibitors are under development as a new class of antiglaucoma agents. Based on the potent ROCK inhibitor H- 1152, previously developed by us, we explored the possibility of related compounds as antiglaucoma agents and synthesized seven types of H-1152-inspired isoquinoline-5- sulfonamide compounds (H-0103–H-0107, H-1001, H-1005). Although all of these ...