Design and synthesis of new adamantyl-substituted antileishmanial ether phospholipids

I Papanastasiou, KC Prousis, K Georgikopoulou…

文献索引：Papanastasiou, Ioannis; Prousis, Kyriakos C.; Georgikopoulou, Kalliopi; Pavlidis, Theofilos; Scoulica, Effie; Kolocouris, Nicolas; Calogeropoulou, Theodora Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 18 p. 5484 - 5487

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被引用次数: 17

摘要

A series of new 2-[3-(2-alkyloxy-ethyl)-adamantan-1-yl]-ethoxy substituted ether phospholipids was synthesized and their antileishmanial activity was evaluated against Leishmania infantum amastigotes. The majority of the new analogues were significantly less cytotoxic than miltefosine while, antiparasitic activity depended on the length of the 2- alkyloxy substituent. The most potent compounds were {2-[[[3-(2-hexyloxy-ethyl)-adamant- ...