Bioorganic & medicinal chemistry letters

Synthesis and biological evaluation of a novel structural type of serotonin 5-HT 3 receptor antagonists

RV Perumal, R Mahesh

文献索引：Venkatesha Perumal, Ramachandran; Mahesh, Radhakrishnan Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 10 p. 2769 - 2772

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被引用次数: 24

摘要

A series of novel 3-substituted quinoxalin-2-carboxamides were designed as per the pharmacophoric requirement for 5-HT3 receptor antagonists and prepared by microwave irradiation and also by conventional method. The compounds were characterized by spectral data (IR, 1H NMR, and MS) and the purity was ascertained by microanalysis. The synthesized compounds were evaluated for 5-HT3 antagonisms in longitudinal muscle- ...