Novel N-substituted benzimidazole CXCR4 antagonists as potential anti-HIV agents

…, KS Gudmundsson, S Jenkinson, A Spaltenstein…

文献索引：Miller, John F.; Turner, Elizabeth M.; Gudmundsson, Kristjan S.; Jenkinson, Stephen; Spaltenstein, Andrew; Thomson, Michael; Wheelan, Pat Bioorganic and Medicinal Chemistry Letters, 2010 , vol. 20, # 7 p. 2125 - 2128

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被引用次数: 43

摘要

The lead optimization of a series of N-substituted benzimidazole CXCR4 antagonists is described. Side chain modifications and stereochemical optimization led to substantial improvements in potency and protein shift to afford compounds with low nanomolar anti-HIV activity.