Chemistry and positive inotropic effect of pelrinone and related derivatives. A novel class of 2-methylpyrimidones as inotropic agents

J Bagli, T Bogri, B Palameta, S Rakhit…

文献索引：Bagli, Jehan; Bogri, T.; Palameta, B.; Rakhit, S.; Peseckis, S.; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, # 4 p. 814 - 823

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被引用次数: 33

摘要

A novel series of pyrimidine derivatives was synthesized and evaluated for positive inotropic activity. Inotropic and chronotropic effects were determined in vitro in cat papillary muscle and right atrium, respectively. Selected compounds were then evaluated in vivo in a dog heart failure model. Changes in ventricular dP/dt, heart rate, and blood pressure were monitored. Several of these agents produced relatively minor changes in heart rate. This ...