Peptide folding induces high and selective affinity of a linear and small β-peptide to the human somatostatin receptor 4

K Gademann, T Kimmerlin, D Hoyer…

文献索引：Journal of Medicinal Chemistry, , vol. 44, # 15 p. 2460 - 2468

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被引用次数: 190

摘要

... Journal of Medicinal Chemistry. ... thus unconstrained β-peptide. The biological active conformation should therefore only be due to the peptide folding and not due to constraints by chemical bonding. We chose, as a ...