前往化源商城

Tetrahedron: Asymmetry

Novel ester linked glycosyl amino acids: convenient building blocks for the synthesis of glycopeptide libraries

RJ Tennant-Eyles, AJ Fairbanks

文献索引:Tennant-Eyles, Richard J.; Fairbanks, Antony J. Tetrahedron Asymmetry, 1999 , vol. 10, # 2 p. 391 - 401

全文:HTML全文

被引用次数: 27

摘要

The completely orthogonally protected aspartic acid derivative FmocAsp (OBn) OtBu is readily synthesized on a large scale. Deprotection of the β-carboxylic acid allows coupling to various sugar derivatives via free hydroxyl groups to produce novel glycosyl amino acids. Subsequent deprotection of either the α-acid or nitrogen is achieved cleanly to allow elaboration into an oligopeptide, whilst selective deprotection of PMB protected sugar ...