Novel human histamine H 3 receptor antagonists

C Shah, L McAtee, JG Breitenbucher, D Rudolph…

文献索引：Shah, Chandra; McAtee, Laura; Breitenbucher, J Guy; Rudolph, Dale; Li, Xiaobing; Lovenberg, Timothy W; Mazur, Curt; Wilson, Sandy J; Carruthers, Nicholas I Bioorganic and medicinal chemistry letters, 2002 , vol. 12, # 22 p. 3309 - 3312

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被引用次数: 53

摘要

High throughput screening, using the recombinant human H3 receptor, was used to identify novel histamine H3 receptor antagonists. Evaluation of the lead compounds ultimately afforded potent, selective, orally bioavailable compounds (eg, 38) with favorable blood– brain barrier penetration.