Photochemistry of flutamide in various media: Investigation of the reaction mechanism as revealed by external magnetic field effects on product yields

C Udagawa, S Fukuyoshi, S Morimoto…

文献索引：Udagawa, Chikako; Fukuyoshi, Shuichi; Morimoto, Shotaro; Tanimoto, Yoshifumi; Nakagaki, Ryoichi Journal of Photochemistry and Photobiology A: Chemistry, 2011 , vol. 226, # 1 p. 57 - 63

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被引用次数: 9

摘要

Photochemistry of an anticancer drug flutamide, 2-methyl-N-[4-nitro-3-(trifluoromethyl) phenyl] propanamide has been investigated in various media in the absence and presence of 0.1 T magnetic field. On photoexcitation flutamide gives rise to a phenol derivative through nitro-to-nitrite rearrangement in homogeneous as well as in inhomogeneous solutions. Magnetic field effects on the product yields revealed that a radical pair is involved in the ...