Organic & biomolecular chemistry

NHC-catalyzed oxidative cyclization reaction for the synthesis of 3-substituted phthalides

SW Youn, HS Song, JH Park

文献索引：Youn, So Won; Song, Hyoung Sub; Park, Jong Hyub Organic and Biomolecular Chemistry, 2014 , vol. 12, # 15 p. 2388 - 2393

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被引用次数: 12

摘要

An efficient NHC-catalyzed domino oxidation/oxa-Michael addition reaction of 2- alkenylbenzaldehydes has been developed to afford 3-substituted phthalides bearing a C3- stereogenic center with a broad substrate scope and wide functional group tolerance. The preliminary results of the asymmetric process have been provided as well.