Steroids

Synthesis of polyhydroxysterols (III): synthesis and structural elucidation of 24-methylenecholest-4-en-3β, 6α-diol

JG Cui, CW Lin, LM Zeng, JY Su

文献索引：Cui, Jian Guo; Lin, Cui Wu; Zeng, Long Mei; Su, Jing Yu Steroids, 2002 , vol. 67, # 13-14 p. 1015 - 1019

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被引用次数: 13

摘要

Using stigmasterol as the starting material, 24-methylenecholest-4-en-3β, 6α-diol (2) was synthesized in eight steps in 13% overall yield. The introduction of the sterol side-chain was carried out using (3-methyl-2-oxobutyl)-triphenylarsonium bromide (11) and K2CO3 in a solid–liquid phase-transfer Wittig reaction. Construction of the steroidal nucleus was finished by oxidation of 24-methylenecholest-5-en-3β-ol (9) with pyridinium chlorochromate (PCC) ...