Synthetic Communications®

Efficient CuCl-Catalyzed Selective and Direct Oxidation of β-and γ-Substituted Aliphatic Primary Alcohols to Carboxylic Acids

S Mannam, G Sekar

文献索引：Mannam, Sreedevi; Sekar, Govindasamy Synthetic Communications, 2010 , vol. 40, # 19 p. 2822 - 2829

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被引用次数: 5

摘要

A new procedure for the selective and direct oxidation of aliphatic primary alcohols having substitution at β-and γ-positions to corresponding carboxylic acids was developed using a catalytic amount of ligand and additive-free CuCl with anhydrous t BuOOH in acetonitrile solvent under very mild reaction conditions. This procedure is very simple and mild and works efficiently without any additives at room temperature.