Superior anticancer activity of halogenated chalcones and flavonols over the natural flavonol quercetin

…, CF Lima, MF Proença, C Pereira-Wilson

文献索引：Dias, Tatiana A.; Duarte, Cecilia L.; Lima, Cristovao F.; Proenca, M. Fernanda; Pereira-Wilson, Cristina European Journal of Medicinal Chemistry, 2013 , vol. 65, p. 500 - 510

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被引用次数: 29

摘要

Abstract A series of chalcone and flavonol derivatives were synthesized in good yield by an eco-friendly approach. A pharmacological evaluation was performed with the human colorectal carcinoma cell line HCT116 and revealed that the anticancer activity of flavonols was higher when compared with that of the respective chalcone precursors. The antiproliferative activity of halogenated derivatives increases as the substituent in the 3-or ...