Tetrahedron letters

3-Oxo 3H-indole from dioxygen copper-catalyzed oxidation of indole: One-flask synthesis of 2-dialkylamino 3-oxo 3H-indoles.

P Capdevielle, M Maumy

文献索引：Capdevielle, Patrice; Maumy, Michel Tetrahedron Letters, 1993 , vol. 34, # 18 p. 2953 - 2956

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被引用次数: 23

摘要

Abstract Cu (I) Cl-catalyzed oxidation of indole 1 by dioxygen in anhydrous acetonitrile leads to highly reactive 3-oxo 3H-indole 2, which provides directly 2-dialkylamino 3-oxo 3H- indoles 3 in presence of dialkylamines. Amidines 3, previously difficult to prepare, are potentially useful synthons in the field of heterocyclic chemistry.