Tetrahedron

1, 3, 4-Oxadiazole formation as traceless release in solid phase organic synthesis

S Cesarini, N Colombo, M Pulici, ER Felder, WKD Brill

文献索引：Cesarini, Sara; Colombo, Nicoletta; Pulici, Maurizio; Felder, Eduard R.; Brill, Wolfgang K.-D. Tetrahedron, 2006 , vol. 62, # 43 p. 10223 - 10236

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被引用次数: 24

摘要

Recent synthesis methodologies making use of solid-support-bound reagents 4 may be highly useful to adapt oxadiazole formation to parallel chemistry. Two reports on the synthesis of oxadiazoles on solid supports have addressed this subject. 5, 5a and 5b Herein we report the development of a method producing libraries of oxadiazoles in an array format with minimal manipulations and independent of the solubility of starting materials or intermediates.