Design and synthesis of boronic acid inhibitors of endothelial lipase

DP O'Connell, DF LeBlanc, D Cromley…

文献索引：O'Connell, Daniel P.; Leblanc, Daniel F.; Cromley, Debra; Billheimer, Jeffrey; Rader, Daniel J.; Bachovchin, William W. Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 3 p. 1397 - 1401

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被引用次数: 15

摘要

Endothelial lipase (EL) and lipoprotein lipase (LPL) are homologous lipases that act on plasma lipoproteins. EL is predominantly a phospholipase and appears to be a key regulator of plasma HDL-C. LPL is mainly a triglyceride lipase regulating (V) LDL levels. The existing biological data indicate that inhibitors selective for EL over LPL should have anti- atherogenic activity, mainly through increasing plasma HDL-C levels. We report here the ...