Inhibitors of polyamine biosynthesis VII: Evaluation of pyruvate derivatives as inhibitors of s??adenosyl??l??methionine decarboxylase

M Pankaskie, MM Abdel??Monem

文献索引：Pankaskie; Abdel-Monem Journal of Pharmaceutical Sciences, 1980 , vol. 69, # 9 p. 1000 - 1004

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被引用次数: 8

摘要

Abstract The mechanism of the enzymatic decarboxylation of S-adenosyl-L-methionine catalyzed by S-adenosyl-L-methionine decarboxylase and its inhibition by methylglyoxal bis (guanylhydrazone) were investigated. The results indicate that the carbonyl group of the