Molecules

Synthesis of 9, 9′-[1, 2-Ethanediylbis (oxymethylene)] bis-2-amino-1, 9-dihydro-6H-purin-6-one, an Impurity of Acyclovir

…, A Molina, A Cosme, JJ Vaquero, J Alvarez-Builla

文献索引：Suarez, Rosa M.; Matia, Maria Paz; Novella, Jose Luis; Molina, Andres; Cosme, Antonio; Vaquero, Juan Jose; Alvarez-Builla, Julio Molecules, 2012 , vol. 17, # 8 p. 8735 - 8741

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被引用次数: 1

摘要

Abstract: The synthesis of 9, 9'-[1, 2-ethanediylbis (oxymethylene)] bis-2-amino-1, 9-dihydro- 6 H-purin-6-one, a minor impurity of acyclovir, is described. Starting with commercial N-(9- acetyl-6-oxo-1 H-purin-2-yl) acetamide, the process uses an acid catalysed phase transfer catalysis (PTC) process to produce the selective alkylation at the 9 position of the guanine ring.