Tetrahedron letters

Fast, easy, solvent-free, microwave-promoted Michael addition of anilines to α, β-unsaturated alkenes: synthesis of N-aryl functionalized β-amino esters and acids

KM Amore, NE Leadbeater, TA Miller, JR Schmink

文献索引：Amore, Kristen M.; Leadbeater, Nicholas E.; Miller, Tyson A.; Schmink, Jason R. Tetrahedron Letters, 2006 , vol. 47, # 48 p. 8583 - 8586

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被引用次数: 51

摘要

The rapid, simple, microwave-promoted synthesis of N-aryl functionalized β-amino esters using Michael addition reactions is presented. Reactions are performed neat at 200° C for 20min and are catalyzed by acetic acid. The esters can be easily hydrolyzed to the corresponding N-aryl functionalized β-amino acids.