In Vitro and in Vivo Antileishmanial and Trypanocidal Studies of New N-Benzene-and N-Naphthalenesulfonamide Derivatives

C Galiana-Roselló, P Bilbao-Ramos…

文献索引：Galiana-Rosello, Cristina; Bilbao-Ramos, Pablo; Dea-Ayuela, M. Auxiliadora; Rolon, Miriam; Vega, Celeste; Bolas-Fernandez, Francisco; Garcia-Espana, Enrique; Alfonso, Jorge; Coronel, Cathia; Gonzalez-Rosende, M. Eugenia Journal of Medicinal Chemistry, 2013 , vol. 56, # 22 p. 8984 - 8998

全文：HTML全文

被引用次数: 11

摘要

We report in vivo and in vitro antileishmanial and trypanocidal activities of a new series of N- substituted benzene and naphthalenesulfonamides 1–15. Compounds 1–15 were screened in vitro against Leishmania infantum, Leishmania braziliensis, Leishmania guyanensis, Leishmania amazonensis, and Trypanosoma cruzi. Sulfonamides 6e, 10b, and 10d displayed remarkable activity and selectivity toward T. cruzi epimastigotes and ...