Bioorganic & medicinal chemistry letters

Substituted coumarins as esterase-sensitive prodrug moieties with improved release rates

Y Liao, B Wang

文献索引：Liao, Yuan; Wang, Binghe Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 13 p. 1795 - 1800

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被引用次数: 16

摘要

Our laboratory has recently reported a coumarin-based prodrug system for the preparation of esterase-sensitive prodrugs of amines, peptides, and peptidomimetics. However, the release from this prodrug system was undesirably slow for some drug moieties. In this report, we describe the synthesis and evaluation of several substituted coumarin-based prodrugs of model amines with significantly increased release rates.