Novel Dual Use of Formamide-POCl3 Mixture for the Efficient, One-Pot Synthesis of Condensed 2 H-Pyrimidin-4-amine Libraries Under Microwave Irradiation

…, MK Kathiravan, JB Bariwal, PK Chaskar…

文献索引：Jain, Kishore S.; Kathiravan, Muthu K.; Bariwal, Jitender B.; Chaskar, Pratip K.; Tompe, Santosh S.; Arya, Nikhilesh Synthetic Communications, 2013 , vol. 43, # 5 p. 719 - 727

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被引用次数: 3

摘要

The novel dual use of formamide-POCl 3 mixture for the incorporation of a CN fragment to form the pyrimidine nucleus and its subsequent chlorination in an efficient, one-pot synthesis of potentially bioactive condensed 2H-pyrimidin-4-amine libraries under microwave irradiation (MWI) is reported. The one-pot microwave-assisted synthetic protocol is high-yielding, ecofriendly, rapid, and novel as well as eliminates intermittent workups. The protocol can be adapted ...