Liebigs Annalen der Chemie

Synthesis of New 2??Azaadenines and 2??Azahypoxanthines from 4??Diazo??4H??imidazoles

KE Andersen, EB Pedersen

文献索引：Andersen, Knud Erik; Pedersen, Erik B. Liebigs Annalen der Chemie, 1986 , # 6 p. 1012 - 1020

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被引用次数: 6

摘要

Abstract 5-Amino-1H-imidazole-4-carboxamide hydrochloride has been converted into a series of new, potentially biologically active N 6-substituted 2-azaadenines 5via 4-diazo-4H- imidazole-5-carbonitrile (1) which was coupled with primary amines to give 5 in 11–78% yield. Further, some 1-substituted 2-azahypoxanthines 9 have been prepared in 17–66% yield from ethyl 5-amino-1H-imidazole-4-carboxylate (6) via ethyl 4-diazo-4H-imidazole-5- ...