Synthesis and in vitro urease inhibitory activity of N, N′-disubstituted thioureas

…, A Khan, S Perveen, MI Choudhary, W Voelter

文献索引：Khan, Khalid Mohammed; Naz, Farzana; Taha, Muhammad; Khan, Ajmal; Perveen, Shahnaz; Choudhary; Voelter, Wolfgang European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 314 - 323

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被引用次数: 29

摘要

Abstract Thiourea derivatives (1–38) were synthesized and evaluated for their urease inhibition potential. The synthetic compounds showed a varying degree of in vitro urease inhibition with IC 50 values 5.53±0.02–91.50±0.08 μM, most of which are superior to the standard thiourea (IC 50= 21.00±0.11 μM). In order to ensure the mode of inhibition of these compounds, the kinetic study of the most active compounds has been carried out. Most of ...