Chemical Communications

Highly efficient copper-catalyzed cascade synthesis of quinazoline and quinazolinone derivatives

C Huang, Y Fu, H Fu, Y Jiang, Y Zhao

文献索引：Huang, Cheng; Fu, Yuan; Fu, Hua; Jiang, Yuyang; Zhao, Yufen Chemical Communications, 2008 , # 47 p. 6333 - 6335

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被引用次数: 93

摘要

We have developed a general and highly efficient copper-catalyzed method for synthesis of quinazoline and quinazolinone derivatives, the target products were obtained in good to excellent yields via cascade reactions of amidine hydrochlorides with substituted 2- halobenzaldehydes, 2-halophenylketones, or methyl 2-halobenzoates, and the method is of simple, economical and practical advantages.