Helvetica chimica acta

Nucleotides. Part LVII.. Synthesis of phosphoramidite building blocks of 2′??amino??2′??deoxyribonucleosides: New compounds for oligonucleotide synthesis

B Greiner, W Pfleiderer

文献索引：Greiner, Beate; Pfleiderer, Wolfgang Helvetica Chimica Acta, 1998 , vol. 81, # 8 p. 1528 - 1544

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被引用次数: 14

摘要

Abstract The chemical synthesis of 2′-amino-2′-deoxyribonucleosides of uracil, cytosine, adenine, and guanine, and their conversion into suitably protected 3′-phosphoramidite building blocks 35–40 for oligonucleotide synthesis are described. The aglycone and the 2′-amino functions were protected using the 2-(4-nitrophenyl) ethoxycarbonyl (npeoc) group. The synthesis of the 3′-O-succinyl (3′-O-(3-carboxypropanoyl))-substituted ...