Modification of human serum albumin with trifluoromethyl-substituted aryl halides and sulfonates

JT Gerig, JD Reinheimer

文献索引：Gerig,J.T.; Reinheimer,J.D. Journal of the American Chemical Society, 1975 , vol. 97, p. 168 - 173

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被引用次数: 31

摘要

Abstract: Reactions of 4-fluoro-3-nitro-, 2-fluoro-4-nitro-, and 4-chloro-2, 6- dinitrobenzotrifluoride and 2.6-dinitro-4-trifluo-romethylbenzenesulfonate with various amino acid and peptide model compounds and with human serum albumin have been examined. Spectroscopic data for the derivatives of the model compounds are reported. Studies of the protein modification reactions suggest that these arylating reagents react by first forming ...