Cationic anthraquinone derivatives as catalytic DNA photonucleases: mechanisms for DNA damage and quinone recycling

B Armitage, C Yu, C Devadoss…

文献索引：Armitage, Bruce; Yu, Changjun; Devadoss, Chelladurai; Schuster, Gary B. Journal of the American Chemical Society, 1994 , vol. 116, # 22 p. 9847 - 9859

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被引用次数: 173

摘要

Abstract: Ammonium-substituted anthraquinone derivatives have been found to catalyze DNA cleavage upon irradiation with 350 nm light. Picosecond laser spectroscopy demonstrates that the excited quinones react with DNA by two separate oxidative pathways: electron transfer from a nearby base and hydrogen atom abstraction from the deoxyribose component of the nucleic acid backbone. Photo-oxidation of DNA by either pathway yields ...