Synthesis of aminomethyl and amino analogs of 5??benzylacyclouridine and 5??benzyloxybenzylacyclouridine

SH Chu, ZH Chen, ZY Weng, EC Rowe…

文献索引：Chu; Chen; Weng; et al. Journal of Heterocyclic Chemistry, 1987 , vol. 24, # 4 p. 989 - 995

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被引用次数: 8

摘要

Abstract Amino analogs of BAU (5-benzylacyclouridine) and BBAU (5- benzyloxybenzylacyclouridine) and their 2′-hydroxymethyl derivatives were synthesized for evaluation as inhibitors of uridine phosphorylase and hence potential cancer chemotherapeutic agents. Both aminomethyl analogs were found to be potent inhibitors of this enzyme and good potentiators of the anti-tumor action of FUdR.