Hydroxyl radical generation via photoreduction of a simple pyridine N-oxide by an NADH analogue

…, K Ohkubo, K Takeshita, KT Suzuki, T Ozawa…

文献索引：Nakanishi, Ikuo; Nishizawa, Chiho; Ohkubo, Kei; Takeshita, Keizo; Suzuki, Kazuo T.; Ozawa, Toshihiko; Hecht, Sidney M.; Tanno, Masayuki; Sueyoshi, Shoko; Miyata, Naoki; Okuda, Haruhiro; Fukuzumi, Shunichi; Ikota, Nobuo; Fukuhara, Kiyoshi Organic and Biomolecular Chemistry, 2005 , vol. 3, # 18 p. 3263 - 3265

全文：HTML全文

被引用次数: 4

摘要

Photoreduction of pyridine N-oxide, which has a key structure of antitumor agents for hypoxic solid tumors, by 1-benzyl-1, 4-dihydronicotinamide in deaerated aprotic media resulted in generation of hydroxyl radical, leading to the oxidation of salicylic acid to 2, 3-and 2, 5-dihydroxybenzoic acids, and catechol.