Functional group diversity in enzymic oxygenation reactions catalyzed by bacterial flavin-containing cyclohexanone oxygenase

BP Branchaud, CT Walsh

文献索引：Branchaud, Bruce P.; Walsh, Christopher T. Journal of the American Chemical Society, 1985 , vol. 107, p. 2153 - 2161

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被引用次数: 102

摘要

Abstract: The bacterial flavoprotein monooxygenase cyclohexanone oxygenase was found by spectrophotometric NADPH consumption assays and product analysis studies to perform oxygenation reactions on ketones, aldehydes, sulfides, selenides, boronic acids, a phosphite ester, and an iodide ion. Kinetic parameters (K,,,, V-) are reported for these substrates. The relevance of these results to possible active oxygen-transfer species in ...