Synthesis of 4-Substituted Imidazo [4, 5-d][1, 2, 3] triazine (2-Azapurine) nucleosides

…, MT Migawa, JC Drach, LB Townsend

文献索引：Krawczyk, Steven; Migawa, Michael T.; Drach, John C.; Townsend, Leroy B. Nucleosides, Nucleotides and Nucleic Acids, 2000 , vol. 19, # 1-2 p. 39 - 68

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被引用次数: 10

摘要

Abstract Several methods for functionalization of the 4-position of imidazo [4, 5-d][1, 2, 3] triazin-4-one were investigated. These investigations were successful and led to the preparation of 4-amino, 4-triazol-1-yl, 4-methoxy, 4-methylthio, 4-methylamino, 4-thio, 4- nitrobenzyl, and 4-unsubstituted 9-(β-D-ribofuranosyl)-imidazo-[4, 5-d][1, 2, 3] triazine (2- azapurine ribosides). The 4-unsubstituted compound (19) was slightly active against ...