Design and synthesis of novel bone-targeting dual-action pro-drugs for the treatment and reversal of osteoporosis

…, R Gibe, A Moreau, MM Morshed, RN Young

文献索引：Arns, Steve; Gibe, Romelo; Moreau, Anne; Monzur Morshed; Young, Robert N. Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 6 p. 2131 - 2140

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被引用次数: 18

摘要

There is an important medical need for effective therapies to redress the general bone loss associated with advanced osteoporosis. Prostaglandin E2 and related EP4 receptor agonists have been shown to stimulate bone regrowth but their use has been limited by systemic side effects. Herein is described the design and synthesis of novel dual-action bone-targeting conjugate pro-drugs where two classes of active agents, a bone growth ...