Deracemisation of β-hydroxy esters using immobilised whole cells of Candida parapsilosis ATCC 7330: substrate specificity and mechanistic investigation
SK Padhi, D Titu, NG Pandian, A Chadha
文献索引：Padhi, Santosh Kumar; Titu; Pandian, N. Ganesh; Chadha, Anju Tetrahedron, 2006 , vol. 62, # 21 p. 5133 - 5140
Deracemisation of aryl substituted β-hydroxy esters by immobilised whole cells of Candida parapsilosis ATCC 7330 gave> 99% ee and up to 75% yield of their corresponding (S)- enantiomers. Mechanistic investigation of the deracemisation reaction carried out using a deuterated substrate, ethyl 3-deutero-3-hydroxy-3-phenyl propanoate revealed that while the (S)-enantiomer remains unreacted the (R)-enantiomer undergoes enantioselective ...
