Design, synthesis and in vitro antimalarial activity of an acylhydrazone library

P Melnyk, V Leroux, C Sergheraert, P Grellier

文献索引：Melnyk, Patricia; Leroux, Virginie; Sergheraert, Christian; Grellier, Philippe Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 1 p. 31 - 35

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被引用次数: 185

摘要

A library of acylhydrazone iron chelators was synthesized and tested for its ability to inhibit the growth of a chloroquine-resistant strain of Plasmodium falciparum. Some of these new compounds are significantly more active than desferrioxamine DFO, the iron chelator in widespread clinical use and also than the most effective chelators.