New types of resorcinarene-based nanoscale container molecules 2 and 3 are described. They feature reversibly folding unimolecular cavities of nanoscale dimensions and~ 800 Å3 internal volume; they are among the largest synthetic unimolecular hosts prepared to date. Two seams of intramolecular hydrogen bonds, provided by 12 secondary amides, control the guest uptake and release. The hydrogen bonds resist the unfolding of the host and ...
