It has been found that the introduction of an alkyl group into the beta position of phenethylamines2 or a-methylphenethylamine~~ lowers the toxicity without appreciably affecting the physiological action. The extension of this study to include the effect of alkylating the carbon atom tearing the hydroxyl in amines of the type CeH&H (OH) CH (R) NHR (R is H or CH3) seemed of interest.
