Science China Chemistry

Design of OFF/ON fluorescent thiol probes based on coumarin fluorophore

W Sun, J Li, WH Li, LJ Su, LP Du, MY Li

文献索引：Sun, Wei; Li, Jing; Li, Wenhua; Su, Lijuan; Du, Lupei; Li, Minyong Science China Chemistry, 2012 , vol. 55, # 9 p. 1776 - 1780

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被引用次数: 1

摘要

Abstract This paper presents a series of first-and second-generation click-modified coumarin- based fluorescent probes for thiols. These molecules demonstrate high turn-on fluorescent response and good selectivity towards aromatic thiols over other relevant reactive sulfur species, reactive oxygen species and common nucleophiles. Moreover, probe 1a can detect thiols in the reduced rabbit plasma sample. Therefore, this approach provides a ...