Archiv der Pharmazie

Synthesis and Local Anesthetic Activity of Some Novel N??[5??(4??Substituted) phenyl??1, 3, 4??oxadiazol??2??yl]??2??(Substituted)??Acetamides

H Rajak, MD Kharya, P Mishra

文献索引：Rajak, Harish; Kharya, Murli Dhar; Mishra, Pradeep Archiv der Pharmazie, 2008 , vol. 341, # 4 p. 247 - 261

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被引用次数: 10

摘要

Abstract A novel series of acetamides carrying substituted-1, 3, 4-oxadiazole moiety were synthesized from reaction of 5-aryl-2-chloroacetamido-1, 3, 4-oxadiazoles with different secondary amines. The local anesthetic potential of the compounds was investigated using rabbit corneal reflex method and guinea pig's wheal derm method. The present work is the only one of its kind reporting local anesthetic activity in acetamide system combined with 1 ...